Chen W.-Y.Tsai J.-W.Ju Y.-R.CHUNG-MIN LIAO2020-01-142020-01-1420100269-7491https://scholars.lib.ntu.edu.tw/handle/123456789/448817The purpose of this paper was to use quantitative systems-level approach employing biotic ligand model based threshold damage model to examine physiological responses of tilapia and freshwater clam to sequential pulsed and fluctuating arsenic concentrations. We tested present model and triggering mechanisms by carrying out a series of modeling experiments where we used periodic pulses and sine-wave as featured exposures. Our results indicate that changes in the dominant frequencies and pulse timing can shift the safe rate distributions for tilapia, but not for that of freshwater clam. We found that tilapia increase bioenergetic costs to maintain the acclimation during pulsed and sine-wave exposures. Our ability to predict the consequences of physiological variation under time-varying exposure patterns has also implications for optimizing species growing, cultivation strategies, and risk assessment in realistic situations. © 2009 Elsevier Ltd. All rights reserved.Arsenic; Ecotoxicology; Fluctuation; Modeling; Pulsed exposure[SDGs]SDG6[SDGs]SDG15Arsenic concentration; Arsenic exposure; Biotic Ligand Model; Dominant frequency; Eco-toxicology; Periodic pulse; Physiological response; Pulse timing; Quantitative systems; Rate distributions; Sine-wave; Threshold damage; Time varying; Triggering mechanism; Arsenic; Cultivation; Risk assessment; Risk management; Physiological models; arsenic; arsenic; cichlid; ecotoxicology; modeling; physiological response; pollution effect; pollution exposure; shellfish; aquaculture; article; bioenergy; computer model; computer prediction; concentration (parameters); controlled study; culture optimization; experimental model; freshwater species; nonhuman; quantitative analysis; system analysis; Tilapia; toxicokinetics; water pollution indicator; Animals; Arsenic; Bivalvia; Environmental Exposure; Environmental Monitoring; Fresh Water; Physiological Processes; Tilapia; Water Pollutants, Chemical; Bivalvia; Tilapiajournal article10.1016/j.envpol.2009.12.0212-s2.0-77949912729https://www2.scopus.com/inward/record.uri?eid=2-s2.0-77949912729&doi=10.1016%2fj.envpol.2009.12.021&partnerID=40&md5=8a336e10c7132926afc170235c988aab