Lu, Ching YiChing YiLuHuang, Zheng YingZheng YingHuangChen, Meng ChinMeng ChinChenLiu, Hui KangHui KangLiuSHOEI-SHENG LEECHIA-CHUAN CHANG2024-03-252024-03-252023-01-0110219498https://scholars.lib.ntu.edu.tw/handle/123456789/641303Boehmeria formosana, with its related species, demonstrates anti-glycemic effect, inhibition of HBV production, anti-cancer activities, etc. Some indolizidine alkaloids from the same genus are bioactive but sensitive to light. To overcome this problem and obtain more phenanthroindolizidine alkaloids, isolation was performed in darkness, yielding 10 new indolizidine alkaloids and 17 known compounds. Among them, seven enhanced glucagon-like receptor 1 (GLP-1) activity at 50 mM, especially 14 and 6 (3.5-and 2.3-fold than the negative control). This procedure yielded bioactive indolizidine alkaloids with novel structures.Boehmeria formosana | GLP-1-enhancing ability | Phenanthroindolizidine alkaloids | Secondary metabolites | α-glucosidase inhibitor[SDGs]SDG3journal article10.38212/2224-6614.34832-s2.0-85179929877https://api.elsevier.com/content/abstract/scopus_id/85179929877