臺大醫院;臺大醫院-內科部;臺大醫院-外科部;臺大醫院雲林分院;臺大醫院-影像醫學部;臺大醫學院-光電生物醫學研究中心;LIAN-YU LINMAO-YUAN SUJIEN-JIUN CHENLING-PING LAIJUEY-JEN HWANGTseng, Chuen-DenChuen-DenTsengYIH-SHARNG CHENHSI-YU YUWEN-YIH TSENGJIUNN-LEE LIN2014-02-142018-07-112014-02-142018-07-11http://ntur.lib.ntu.edu.tw//handle/246246/259539OBJECTIVES This study evaluated whether the conductive channel (CC) identified by late gadolinium enhanced-cardiac magnetic resonance (LGE-CMR) is associated with ventricular tachycardia (VT) in patients with systolic heart failure (HF). BACKGROUND One recent study demonstrated that the CC formed by heterogeneous tissue within the core scar could be detected by LGE-CMR and that the CC is responsible for clinical VT. We hypothesized that the CC could help identify HF patients at risk for VT. METHODS A total of 63 patients from a CMR database with left ventricular ejection fraction (LVEF) below 50% and with hyperenhancement on LGE-CMR were included. The cine and LGE images were analyzed to derive the LV function and scar characteristics, and to identify the CC. The outcomes, including VT, ventricular fibrillation (VF), and total mortality, were obtained by reviewing medical records. RESULTS After a median 1,379 (interquartile range: 271 to 1,896) days of follow-up, 8 patients had VT/VF attacks and 14 patients died. Among the CMR-measured parameters, only the probability of identifying the CC by LGE-CMR was higher in patients with VT/VF than those without VT/VF (75.0% vs. 16.4%, p < 0.001). The probability of identifying the CC was also higher in the total mortality group than the survival group (50.0% vs. 16.3%, p = 0.004). The other LGE-CMR variables were not significantly different between the 2 groups. A univariate Cox regression model showed that CC identification was positively associated with VT/VF attacks (hazard ratio [HR]: 27.032, 95% confidence interval [CI]: 3.291 to 222.054, p = 0.002) and excess total mortality (HR: 4.766, 95% CI: 1.643 to 13.824, p = 0.004). The LVEF was inversely associated with VT/VF attacks (HR: 0.119, 95% Cl: 0.015 to 0.977, p = 0.048) and excess total mortality (HR: 0.491, 95% Cl: 0.261 to 0.925, p = 0.028) during follow-up. CONCLUSIONS We demonstrated that CC identification using LGE-CMR can help identify HF patients at risk for VT/VF.(C) 2013 by the American College of Cardiology Foundation108 bytestext/htmlconductive channelcongestive heart failuremagnetic resonance imagejournal articlehttp://ntur.lib.ntu.edu.tw/bitstream/246246/259539/1/index.html