Chien M.-HYeh C.-BLi Y.-CLING-HUNG WEIChang J.-HPeng Y.-TYang S.-FKuo W.-H.2020-02-122020-02-1220110022-4790https://scholars.lib.ntu.edu.tw/handle/123456789/458232Background and Objectives Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide, and the second leading cause of death from cancer in Taiwan. Interleukin-8 (IL-8) is an angiogenic chemokine with important roles in the development and progression of many human malignancies including HCC. This study investigates the effects of single-nucleotide polymorphisms (SNPs) in the IL-8 gene on the susceptibility and clinicopathological characteristics of HCC. Methods One hundred thirty-one HCC patients and 340 control subjects were analyzed for four IL-8 SNPs (-251 T/A, +781 C/T, +1633 C/T, and +2767 A/T) using PCR-RFLP genotyping analysis. Results After adjusting for other confounders, results show that individuals with the IL-8 +781 T/T polymorphic genotype had a significantly lower risk of developing HCC than those with the wild-type (C/C) genotype (AOR = 0.346; 95% CI: 0.132-0.909). Multiple regression analysis showed that the presence of T/A or A/A at IL-8 -251 may indicate higher potential risk of hepatitis B infection (AOR = 2.847; 95% CI: 1.083-8.656). Additionally, these four IL-8 SNPs did not associate with liver-related clinicopathological markers in serum. Conclusions Genetic polymorphism at IL-8 +781 is an important factor in determining susceptibility to HCC in the Taiwanese population. J. Surg. Oncol. 2011; 104:798-803. ? 2011 Wiley Periodicals, Inc. Copyright ? 2011 Wiley Periodicals, Inc.genetic polymorphism; hepatocellular carcinoma; interleukin-8[SDGs]SDG3interleukin 8; adult; article; cancer risk; cancer susceptibility; case control study; controlled study; female; gene mutation; genetic analysis; genotype; human; liver cell carcinoma; major clinical study; male; polymerase chain reaction; priority journal; restriction fragment length polymorphism; single nucleotide polymorphism; Asian Continental Ancestry Group; Carcinoma, Hepatocellular; Case-Control Studies; Female; Genetic Predisposition to Disease; Humans; Interleukin-8; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Polymorphism, Single Nucleotide; Retrospective Studies; Taiwanjournal article10.1002/jso.22037217801292-s2.0-80255124785