The naturally occurring PKC inhibitor sphingosine and tumor promoter phorbol ester potentially induce tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase FA/GSK-3alpha in a common signalling pathway

Lee, S.-C.S.-C.LeeKuan, C.-Y.C.-Y.KuanWen, Z.-D.Z.-D.WenYang, S.-D.S.-D.Yang2021-05-172021-05-171998https://scholars.lib.ntu.edu.tw/handle/123456789/560924When serum-starved A431 cells were treated with 200 nM phorbol ester TPA for 15 min, the cellular activity of protein kinase FA/glycogen synthase kinase-3alpha (kinase FA/GSK-3alpha) could be decreased to approximately 25% of control. Conversely, when treated with 1 microM TPA for 24 hr, the activity could be reversibly increased to approximately 200% of Control.enProline-directed protein kinase FA/GSK-3aprotein kinase csphingosineTPAsignal transductiontyrosine phosphorylationThe naturally occurring PKC inhibitor sphingosine and tumor promoter phorbol ester potentially induce tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase FA/GSK-3alpha in a common signalling pathwayjournal article10.1023/a:1022582312954