Huang X.-B.Zhang W.-Q.Tang W.-W.Liu Y.Ning Y.Huang C.Liu J.-X.Yi Y.-J.Xu R.-H.TZUNG-DAU WANG2020-12-012020-12-0120202045-2322https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091404717&doi=10.1038%2fs41598-020-72780-3&partnerID=40&md5=4e90920615f453dce794951535481e1fhttps://scholars.lib.ntu.edu.tw/handle/123456789/523270Hyperuricemia is prevalent throughout the world. However, a well-designed large-scale epidemiological investigation of hyperuricemia in southwestern China is lacking. A regional representative sample of 10,141 participants were included using multistage, stratified sampling in Chengdu and Chongqing from September 2013 to March 2014. Hyperuricemia was defined as the self-reported of the doctor's diagnosis of hyperuricemia, or serum uric acid > 420?μmol/L in men or serum uric acid > 360?μmol/L in women. The overall age- and sex-standardized prevalence of hyperuricemia among adults aged 35–79?years was 13.5%. Compared with women, the prevalence of hyperuricemia in men was higher (17.3% versus 10.0%). Hypertension, hyperlipidemia, overweight or obesity, central obesity were associated with an increased risk for hyperuricemia both in men and in women. Married men and women were not susceptible to hyperuricemia. Current cigarette smoking was an associated risk factor of hyperuricemia only in women. Hyperuricemia has become a major health problem among urban adults aged 35–79?years in southwestern China, and special attention should be paid to men. Comorbidities associated with hyperuricemia and causality worth further investigation. ? 2020, The Author(s).[SDGs]SDG3uric acid; adult; aged; blood; China; comorbidity; cross-sectional study; demography; female; human; hyperuricemia; male; middle aged; prevalence; risk factor; urban population; Adult; Aged; China; Comorbidity; Cross-Sectional Studies; Female; Humans; Hyperuricemia; Male; Middle Aged; Prevalence; Residence Characteristics; Risk Factors; Urban Population; Uric Acidjournal article10.1038/s41598-020-72780-3329733082-s2.0-85091404717