Chang R.Tsai W.-B.2019-05-282019-05-28201820734360https://scholars.lib.ntu.edu.tw/handle/123456789/410734Temperature stimulus, easy modulation in comparison to other environmental stimuli, makes thermo-responsive nanocarriers popular in the applications of controlled drug release for cancer therapy. In this study, photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive polymeric nanogels consisted of N-isopropylacrylamide and N-(hydroxymethyl)acrylamide. Significant heat was generated from the SCC-containing nanogels under the exposure to 532-nm green laser, and resulted in cell mortality. The thermo-responsive nanogel loaded with 5-FU, an anti-cancer drug, released the drug explosively when exposed to green laser. The combination of hyperthermia and temperature-induced drug release via green laser irradiation greatly enhanced cell mortality to a maximal extent. Such photothermo-responsive nanogel possesses a great potential in anti-cancer treatment. ? 2018 by the authors.Anti-cancerDrug deliveryN-isopropylacrylamideNanogelPhotothermo-responsiveSodium copper chlorophyllin[SDGs]SDG3Acrylic monomers; Amides; Diseases; Drug delivery; Nanostructured materials; Oncology; Targeted drug delivery; Anti-cancer; N- isopropylacrylamide; Nanogels; Photothermo-responsive; Sodium copper chlorophyllin; Controlled drug deliveryjournal article10.3390/polym101010982-s2.0-85054504119https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054504119&doi=10.3390%2fpolym10101098&partnerID=40&md5=544c0fe4873d78179aa05e4ee87a3512