Higuchi W.Hung W.-C.Takano T.Iwao Y.Ozaki K.Isobe H.LEE-JENE TENGShimazaki T.Honda A.Higashide M.Hanaki H.Yamamoto T.2020-06-302020-06-3020101341-321Xhttps://scholars.lib.ntu.edu.tw/handle/123456789/506826Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), which often produces Panton-Valentine leucocidin (PVL), has emerged worldwide as a life-threatening pathogen. Herein, we describe molecular characteristics of MRSA isolated from abdominal cellulitis in a 7-year-old Japanese boy. This MRSA was PVL-positive and belonged to the Taiwanese multiple drug-resistant CA-MRSA clone with the genotype of ST59, staphylococcal cassette chromosome mec (SCCmec) VII (SCCmecV, according to recent reclassification), agr1a (a novel agr1 subtype), and SaPI (which carried seb1, a newly designated variant seb gene). This study demonstrates the first isolation of the Taiwanese PVL-positive ST59 MRSA clone in Japan. The data also demonstrate novel subtypes in agr1 and seb and suggest that a combination of agr1a, seb1, and PVL could contribute to cellulitis (and its recurrence). Recently, a variety of PVL-positive MRSA clones are accumulating in Japan. ? 2010 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.Cellulitis; Child; Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA); Panton-Valentine leucocidin (PVL)[SDGs]SDG3agr1 protein; agr1a protein; ampicillin; bacterial protein; biapenem; cefazolin; cefdinir; cefotaxime; cefotiam; cefoxitin; cefpirome; flomoxef; gentamicin; habekacin; imipenem; kanamycin; latamoxef; linezolid; macrolide; mec protein; meropenem; oxacillin; panipenem; Panton Valentine leukocidin; quinoline derived antiinfective agent; seb1 protein; streptomycin; teicoplanin; unclassified drug; unindexed drug; vancomycin; abdomen; antibiotic sensitivity; article; bacterium isolation; case report; cellulitis; child; clone; gene cassette; genotype; human; Japanese; male; methicillin resistant Staphylococcus aureus; methicillin resistant Staphylococcus aureus infection; multidrug resistance; nonhuman; nucleotide sequence; school child; Taiwanjournal article10.1007/s10156-010-0029-9201431182-s2.0-77952236566