Lai T.C.Yu J.Tsai W.B.2019-05-242019-05-24201620507518https://scholars.lib.ntu.edu.tw/handle/123456789/410342In this work, methacrylated gelatin (GelMA) based hydrogels were fabricated with carboxybetaine methacrylate (CBMA) to manipulate the properties of the gelatin-based hydrogels, since CBMA is a much smaller compound compared to gelatin. With the incorporation of CBMA, these hydrogels demonstrated better mechanical properties, a slower degradation rate, and a controlled drug release rate compared with the GelMA alone group. GelMA/CBMA hydrogels also showed good cell viability. As in the in vivo test, vascular endothelial growth factor (VEGF)-loaded GelMA/CBMA hydrogels displayed certain degrees of angiogenesis. These results indicate that GelMA/CBMA hydrogels are biocompatible, and the properties of GelMA/CBMA hydrogels can be easily tuned with the ratio of CBMA. These characteristics make the GelMA/CBMA hydrogel a promising material for drug delivery and tissue engineering. ? The Royal Society of Chemistry 2016.[SDGs]SDG3journal article10.1039/c5tb02518d2-s2.0-84962106832https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962106832&doi=10.1039%2fc5tb02518d&partnerID=40&md5=a09b1e3f4859cc6e69485382dedc2513