PO-REN HSUEHShyr J.-M.Wu J.-J.2020-12-182020-12-1820061198-743Xhttps://scholars.lib.ntu.edu.tw/handle/123456789/528831Measures to alleviate the growing problem of macrolide resistance in Taiwan resulted in a decrease in macrolide consumption, from 0.629 defined daily doses/1000 inhabitants per day (DIDs) in 1999 to 0.301 DIDs in 2003 (a reduction of 52%). A linear relationship was observed between the decline in erythromycin consumption and the decline in erythromycin resistance in Streptococcus pyogenes (46% in 1999 vs. 17% in 2003; p < 0.001) and azithromycin resistance in Haemophilus influenzae (31% in 2000 vs. 0% in 2003; p < 0.001). However, the rate of erythromycin resistance in Streptococcus pneumoniae showed a continued increase, from 80.2% in 1999 to 92% in 2003. ? 2006 Copyright by the European Society of Clinical Microbiology and Infectious Diseases.[SDGs]SDG3azithromycin; clarithromycin; erythromycin; macrolide; roxithromycin; antibiotic resistance; antibiotic sensitivity; article; bacterium isolate; controlled study; drug use; Haemophilus influenzae; nonhuman; priority journal; statistical significance; Streptococcus pneumoniae; Streptococcus pyogenes; Taiwan; Bacteria (microorganisms); Haemophilus influenzae; Streptococcus; Streptococcus pneumoniae; Streptococcus pyogenesjournal article10.1111/j.1469-0691.2005.01348.x164514212-s2.0-33644894215