LI-HUI TSENGChuang S.-M.Lee T.-Y.TSANG-MING KO2022-03-102022-03-1019940932-0067https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028555884&doi=10.1007%2fBF02335088&partnerID=40&md5=adf6e70341eed6e23394882d18ea163dhttps://scholars.lib.ntu.edu.tw/handle/123456789/597164A family with three children who had Down's syndrome and one healthy child is reported. Cytogenetic studies of the peripheral blood revealed trisomy 21 in the affected children, and normal karyotypes in both the parents and the healthy child. However, a biopsy of the mother's right ovary showed a mosaic trisomy 21 cell line (8/20 cells). By DNA polymorphism analysis, segregation of trisomy oogonia appeared to be the cause of recurrent trisomy 21.[/p] ? 1994 Springer-Verlag.DNA polymorphism analysis; Mosaicism; Trisomy 21[SDGs]SDG3adult; article; blood; blood analysis; clinical article; cytogenetics; dna polymorphism; down syndrome; female; human; karyotype; male; mosaicism; oocyte; ovary; recurrent disease; trisomy 21; Adult; Case Report; Down Syndrome; Female; Human; Mosaicism; Oogonia; Ovary; Polymorphism (Genetics)journal article10.1007/BF0233508876953692-s2.0-0028555884