Wu C.-W.HAO-CHUN CHANGChen T.-H.Huang H.-T.CHIA-JUNG LIUHAO-CHIEN WANG2020-08-122020-08-1220181016-7390https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058212885&doi=10.6314%2fJIMT.201810-29%285%29.02&partnerID=40&md5=76672064ef145ebce011e7367a484342https://scholars.lib.ntu.edu.tw/handle/123456789/512194Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic, and idiopathic interstitial pneumonia. It's prone to elderlies, and the disease involvement is confined to the lungs. There has a unique pathological findings called usual interstitial pneumonia (UIP) that can be found in both histology and images on computer tomography (CT). To make the diagnosis of IPF, all known-cause of interstitial lung diseases such as environmental factors, medications, connective tissue diseases should be excluded first. In the past, IPF is considered as a poorly prognostic disease, while the median survival time was 0.9 year in Taiwan. However, as the pathogenesis is being studied, anti-fibrotic drugs (nintedanib and pirfenidone) have been developed. They were proved to be effective to decrease lung function decline in some large-scale studies. Moreover, there are more ongoing studies among IPF trying to improve prognosis of IPF patients. ? 2018 Society of Internal Medicine of Taiwan. All rights reserved.[SDGs]SDG3nintedanib; pirfenidone; Article; computer assisted tomography; disease course; environmental factor; fibrosing alveolitis; histology; human; internal medicine; interstitial pneumonia; lung fibrosis; lung function; median survival time; prognosisjournal article10.6314/JIMT.201810-29(5).022-s2.0-85058212885