2023-02-152024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/651541生物降解型Mg-Ca合金植體，其重量密度與楊氏彈性模數接近人體骨骼，不會發生應力遮蔽效應，而且鎂、鈣都是人體必須的營養元素，無細胞毒性問題，於心血管支架、傷口癒合裝置與骨科植體等生醫領域具有高度的應用發展潛力。然而Mg-Ca合金的降解速率過快，恐怕無法持久提供足夠的支撐力量，也可能會造成體內pH值上升及產生過量氫氣而引發細胞發炎、血管堵塞等等負面問題。因而本研究計畫擬應用電漿增益型原子層沉積(PEALD)技術，搭配多層薄膜結構設計，於Mg-Ca合金表面鍍製ZrO2/Al2O3多層複合薄膜，探討結構效應對於Mg-Ca合金植體之腐蝕防護機制及其成效，並進行生物相容性測試及動物試驗，實質評估ZrO2/Al2O3多層複合薄膜應用於Mg-Ca合金植體腐蝕防護及調控降解速率之適用性。計畫將分三年進行: (1)第一年度主要研發適用於Mg-Ca合金基材施鍍ZrO2/Al2O3多層複合薄膜之PEALD沉積參數，並進行此多層複合薄膜之厚度量測、結構鑑定及顯微組織觀察，期以建立其最佳化製程技術；(2) 第二年度主要應用前一年建立之最佳化PEALD製程技術，於Mg-Ca合金基材施鍍ZrO2/Al2O3多層複合薄膜，進行其薄膜附著力、腐蝕特性、及降解速率控制等之分析評估，並比較其與單層薄膜各相關性能之差異，且闡明ZrO2/Al2O3多層複合薄膜之腐蝕防護機制。(3)第三年度則依據第一、二年度之研究結果，將最佳化ZrO2/Al2O3多層複合薄膜，施鍍於Mg-Ca合金基材與骨釘植體，進行其生醫特性及動物試驗等之研究分析，進而綜合評估ZrO2/Al2O3多層複合薄膜於生物降解型骨科植體之應用效能。 The density and Young`s modulus of elasticity of biodegradable Mg-Ca alloy implants are close to the human skeleton, and there is no stress shielding effect. Moreover, magnesium and calcium are essential nutrients without toxicity for human body. Therefore, Mg-Ca alloy has high application potential in the fields of cardiovascular stent, wound healing device and orthopedic implant. However, the degradation rate of Mg-Ca alloy is too fast to provide enough support for a long time, and it may also cause pH rise and excessive hydrogen production in vivo, which may lead to cell inflammation, vascular blockage, and other negative problems. This project will use the plasma-enhanced atomic layer deposition (PEALD) technique and the multilayer film structure design to deposit ZrO2/Al2O3 multilayer composite film on the surface of Mg-Ca alloy. We aim at investigating the corrosion protection mechanism and effectiveness of structural effects on Mg-Ca alloy implants. The biocompatibility and animal tests will also be carried out to evaluate the applicability of ZrO2/Al2O3 multilayer composite films in corrosion protection and degradation rate control of Mg-Ca alloy implants. In the first year, we will mainly research and develop PEALD deposition parameters suitable for coating ZrO2/Al2O3 multilayer composite films on Mg-Ca alloy substrates, and carry out thickness measurement, structural identification, and microstructure observation of the multilayer composite films, with a view to establishing its optimal process technology. In the second year, ZrO2/Al2O3 multilayer composite films will be deposited on Mg-Ca alloy substrates by using the optimized PEALD process technology established in the previous year. The adhesion, corrosion characteristics and degradation rate control of the films will be analyzed and evaluated. The differences in the relevant properties of multilayer and single-layer films will be compared. The corrosion protection mechanism of ZrO2/Al2O3 multilayer composite films will be clarified. In the third year, based on the research results of the first and second years, the optimized ZrO2/Al2O3 multilayer composite films will be deposited on Mg-Ca alloy substrates and bone nail implants, and their biomedical characteristics and animal experiments will be analyzed, and then the application performance of ZrO2/Al2O3 multilayer composite films in biodegradable orthopedic implant will be comprehensively evaluated.電漿增益型原子層沉積;生物降解型金屬植體;鎂鈣合金;腐蝕防護;降解速率;生物相容性;Plasma-enhanced Atomic Layer Deposition;Biodegradable Metallic Implants;Magnesium-Calcium Alloys;Corrosion Protection;Degradation Rate;Biocompatibility