YI-TSEN LINCHIH-FENG LINChang C.-H.TE-HUEI YEH2022-01-192022-01-1920190001-6489https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061062132&doi=10.1080%2f00016489.2018.1552368&partnerID=40&md5=7dbaec0695cb675f24b1505167f4998ahttps://scholars.lib.ntu.edu.tw/handle/123456789/592651Background: The role of allergy in the development of chronic rhinosinusitis (CRS) in East Asians is not clear. Aims/objectives: The aim was to investigate the impact of allergies in the clinical characteristics of chronic rhinosinusitis. Material and methods: A total of 138 CRS patients who underwent endoscopic sinus surgery were included. A brief history of rhinosinusitis symptoms, blood eosinophil count, blood-specific allergen tests, computed tomography (CT) scan findings, Lund-Mackay (LM) CT scores, and Sino-Nasal Outcome Test (SNOT-22) Questionnaire scores, and sinoscopy findings at 3 and 6?months postoperatively. Results: The ImmunoCAP test was positive in 71(51%) patients and negative in 67(49%) patients. The mean age of those who received endoscopic sinus surgery was 7-years younger in the allergic group compared with the non-allergic group (p =.008). The peripheral eosinophil count in the allergic group was higher than that of the non-allergic group (p =.008). The LM scores and SNOT-22 scores were not significantly different between the two groups. The recurrence rate of nasal polyps in the allergic group was higher but without statistical significance. Conclusions and significance: Allergy may accelerate the disease progression of CRS. The presence of the serum-specific IgE was correlated with peripheral eosinophil percentage, especially in the CRSwNP patients. ? 2019, ? 2019 Acta Oto-Laryngologica AB (Ltd).Allergy; chronic rhinosinusitis; eosinophil; Lund-Mackay score; SNOT-22[SDGs]SDG3immunoglobulin E; adult; allergy; Article; asthma; atopic dermatitis; chronic rhinosinusitis; computer assisted tomography; disease course; disease severity; endoscopic sinus surgery; eosinophil count; female; human; immunoglobulin blood level; major clinical study; male; nose polyp; postoperative period; priority journal; recurrent disease; retrospective study; aged; allergic rhinitis; chronic disease; complication; disease exacerbation; middle aged; nose polyp; sinusitis; Adult; Aged; Chronic Disease; Disease Progression; Female; Humans; Male; Middle Aged; Nasal Polyps; Retrospective Studies; Rhinitis, Allergic; Sinusitisjournal article10.1080/00016489.2018.1552368307144582-s2.0-85061062132