YI-LWUN HOYEN-HUNG LINCHII-MING LEERON-BIN HSUTing H.-T.NAI-KUAN CHOUCHIA-LUN CHAOSHOEI-SHEN WANGHsu H.-C.MING-FONG CHEN2020-03-052020-03-0520090009-9120https://www.scopus.com/inward/record.uri?eid=2-s2.0-69249229547&doi=10.1016%2fj.clinbiochem.2009.06.013&partnerID=40&md5=00df3c777699c941d092340b69f422a5https://scholars.lib.ntu.edu.tw/handle/123456789/471034Objectives: To perform risk stratification by serum adipocytokines and serum markers of extracellular matrix in heart failure patients with high b-type natriuretic peptide (BNP). Methods: Patients with heart failure were enrolled in this study. Serum adipocytokines and serum markers of extracellular matrix were analyzed. Results: In total, 131 patients were enrolled and followed-up for 240 ± 174?days. Mortality was significantly associated with adiponectin, resistin, type III amioterminal propeptide of procollagen (PIIINP), matrix metalloproteinase-2 (MMP-2), tissue inhibitor of metalloproteinase 1 (TIMP-1), and serum creatinine. Heart failure-related admission was significantly associated with apelin, and PIIINP. Cox regression analysis identified that mortality and heart failure-related admissions were significantly associated with MMP-2 (P = 0.008) and PIIINP (P = 0.011), respectively. Conclusions: Serum markers of extracellular matrix rather than adipocytokines may warrant further risk stratification for impacting the prognosis of patients with heart failure with high BNP. ? 2009 The Canadian Society of Clinical Chemists.[SDGs]SDG3journal article10.1016/j.clinbiochem.2009.06.013195604522-s2.0-69249229547