Huang Y.-HChang Y.-HKuan D.-HHuang J.-CHuang Y.-JCHIH-TING LINNIEN-TSU HUANG2021-09-022021-09-022018https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079812118&partnerID=40&md5=911c03f99d3502cfb5d55717568b19ebhttps://scholars.lib.ntu.edu.tw/handle/123456789/581071In this paper, we demonstrate a microfluidic platform integrating ion-sensitive field-effect transistor (ISFET) sensor to achieve on-chip whole blood processing and in-situ glycated hemoglobin (HbA1c) detection. The whole blood sample could be lysed, removal of debris and uniform mixed and diluted by PBS using a serpentine channel with a series of dam structures in the microfluidic device. Next, the lysed and diluted blood sample would flow into ISFET sensor chamber for HbA1c sensing. The entire whole blood processing followed by molecule sensing could be completed in a single chip within 40 minutes. Copyright ? (2018) by Chemical and Biological Microsystems Society. All rights reserved.Glycated hemoglobin; Ion-sensitive field-effect transistor; MicrofluidicsBlood; Hemoglobin; In situ processing; Ions; Microfluidics; Serpentine; Blood samples; Dam structure; Glycated hemoglobin (HbA1c); Glycated hemoglobins; Micro-fluidic devices; Microfluidic platforms; Processing platform; Serpentine channel; Ion sensitive field effect transistorsconference paper2-s2.0-85079812118