YEN-HUNG LINLin C.Lo M.-T.HUNG-JU LINYEN-WEN WURON-BIN HSUCHIA-LUN CHAOHsu H.-C.Wang P.-C.VIN-CENT WUSHOEI-SHEN WANGCHII-MING LEEKUO-LIONG CHIENYI-LWUN HOMING-FONG CHENPeng C.-K.2020-03-052020-03-052010-121434-6621https://www.scopus.com/inward/record.uri?eid=2-s2.0-79251510542&doi=10.1515%2fCCLM.2010.348&partnerID=40&md5=12ce4454f5ca3b2d37a6491ff074054bhttps://scholars.lib.ntu.edu.tw/handle/123456789/471015Background: Cardiac extra-cellular matrix (ECM) fibrosis plays an important role in the pathophysiology of heart failure (HF). It may provide electrical heterogeneity and a substrate for arrhythmogenicity, which may cause sudden cardiac death (SCD). Methods: Twenty-one patients with manifestations of HF and a left ventricular ejection fraction (LVEF) ?50% were enrolled. The median age was 62 years and median LVEF was 33%. Time- and frequency-domain analysis of heart rate variability (HRV) on 24 h ambulatory electrocardiography recording was assessed. Serum markers of ECM turnover including type I and III aminoterminal propeptide of procollagen (PINP and PIIINP), matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) were analyzed. Results: The serum PIIINP concentration was correlated significantly with standard deviation of all normal to normal R-R intervals (SDNN) (r=-0.722, p=<0.001), percentage of adjacent NN interval differences >50 ms (pNN50) (r=-0.528, p=0.014), percentage of adjacent NN interval differences >20 ms (pNN20) (r=-0.545, p=0.002), very low frequency (VLF) (r=-0.490, p=0.024), low frequency (LF) (r=-0.491, p=0.024), and high frequency (HF) (r=-0.513, p=0.018). PINP, MMP-2, -9, TIMP-1 were not correlated with time- and frequency-domain analysis of HRV. Conclusions: PIIINP was significantly correlated with time- and frequency-domain analysis of HRV in HF patients. PIIINP is a potential serological marker to evaluate cardiac autonomic control and risk of SCD in HF patients. ? 2010 by Walter de Gruyter Berlin New York.en[SDGs]SDG3journal article10.1515/CCLM.2010.348208461042-s2.0-79251510542