Cheng W.-CLiu W.-JHu K.-HTan Y.-LLin Y.-TChen W.-ALEE-CHIANG LO2021-08-032021-08-03202021568952https://www.scopus.com/inward/record.uri?eid=2-s2.0-85095861166&doi=10.1021%2facscombsci.0c00011&partnerID=40&md5=3932db7db43c7300a13884de4457398dhttps://scholars.lib.ntu.edu.tw/handle/123456789/575807The preparation of natural product-inspired nucleoside analogs using solution-phase parallel synthesis is described. The key intermediates containing alkyne and N-protected amino moieties were developed to allow for further skeleton and substituent diversity using click chemistry and urea or amide bond formation. Rapid purification was accomplished using solid-phase extraction. The obtained library comprised 80 molecules incorporating two diversity positions and one chiral center, each of which was efficiently prepared in good purity and acceptable overall yield. A bacterial morphology study was also performed. ? 2020 American Chemical Society. All rights reserved.[SDGs]SDG3journal article10.1021/acscombsci.0c00011328334252-s2.0-85095861166