Age, sex and vitamin status affect plasma level of homocysteine, but hyperhomocysteinaemia is possibly not an important risk factor for venous thrombophilia in Taiwanese Chinese

Lin, Jen-ShiouJen-ShiouLinMING-CHING SHENWERN-CHERNG CHENGWOEI TSAYWang, Ying-ChiYing-ChiWangLin, Bin-BinBin-BinLinHung, Mei-HuaMei-HuaHung2021-05-052021-05-0520020007-1048https://scholars.lib.ntu.edu.tw/handle/123456789/559477http://ntur.lib.ntu.edu.tw//handle/246246/225801The biological effects of age, sex and vitamin status on plasma total homocysteine (tHcy), and association of hyperhomocysteinaemia with venous thromboembolism in Taiwanese Chinese individuals, were investigated. Eighty patients (16-85 years) with venous thrombophilia and 123 healthy subjects (15-85 years) without history of vascular thrombosis were studied for plasma levels of tHcy, folate and vitamin B12. A multivariate analysis in healthy subjects revealed that plasma tHcy levels tended to increase with age (P < 0.001) and with decreasing plasma levels of folate (P = 0.001) or vitamin B12 (P < 0.029); men tended to have higher plasma tHcy levels than women (P = 0.006). Thrombotic risk assessment in a case-control study demonstrated that neither plasma level of tHcy [odds ratio (OR), 1.07; 95% confidence interval (CI), 0.96-1.18; P = 0.210] nor hyperhomocysteinaemia (OR, 1.65; 95% CI, 0.50-5.49; P = 0.415) was significantly associated with venous thrombophilia. The relationship between hyperhomocysteinaemia and recurrence of episode remained insignificant (P = 0.560). We conclude that age, sex and vitamin status affect plasma tHcy but hyperhomocysteinaemia is possibly not an important risk factor for venous thrombophilia in Taiwanese Chinese.en[SDGs]SDG3cyanocobalamin; folic acid; homocysteine; adolescent; aged; anamnesis; article; blood level; Chinese; confidence interval; controlled study; disease association; female; human; hyperhomocysteinemia; major clinical study; male; multivariate analysis; patient care; priority journal; recurrent disease; risk assessment; risk factor; Taiwan; thrombophilia; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Case-Control Studies; China; Female; Folic Acid; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nutritional Status; Odds Ratio; Risk Factors; Sex Factors; Taiwan; Thrombophilia; Vitamin B 12Age, sex and vitamin status affect plasma level of homocysteine, but hyperhomocysteinaemia is possibly not an important risk factor for venous thrombophilia in Taiwanese Chinesejournal article10.1046/j.1365-2141.2002.03384.x119185482-s2.0-0036226431