Fluid administration prevents renal dysfunction during hypotension under spinal anesthesia in a rat model

YA-JUNG CHENGChien, Chiang-TingChiang-TingChienYONG-PING WANGFu, Tsu-ChingTsu-ChingFuChen, Ta-LiangTa-LiangChenChen, Chau-FongChau-FongChen2023-12-142023-12-142003-030254-1319https://scholars.lib.ntu.edu.tw/handle/123456789/637844Severe hypotension deteriorates renal functions and renal hemodynamics especially renal cortical blood flow. Systemic hypotension following high level spinal anesthesia may impair renal functions in spite of the blockade of renal sympathetic nerves that may help prevent vasoconstriction. Fluid loading is clinically applied for preventing hypotension but the effects on the changes of renal functions have not been studied. This study was designed to investigate the effects of fluid loading on systemic hemodynamics, renal hemodynamics and functions especially the blood distribution to renal cortex.enAnesthesia, spinal | Kidney function tests, microcirculationFluid administration prevents renal dysfunction during hypotension under spinal anesthesia in a rat modeljournal article127473412-s2.0-0344211403https://api.elsevier.com/content/abstract/scopus_id/0344211403