Huang, C.-Y.C.-Y.HuangTseng, Y.-J.Y.-J.TsengChokkalingam, U.U.ChokkalingamHwang, T.-L.T.-L.HwangHsu, C.-H.C.-H.HsuCHANG-FENG DAISung, P.-J.P.-J.SungSheu, J.-H.J.-H.Sheu2018-09-102018-09-102016http://www.scopus.com/inward/record.url?eid=2-s2.0-84971449677&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/396324Four new isoprenoids, including two norcembranoids sinulerectols A and B (1 and 2), a cembranoid sinulerectol C (3), and a degraded cembranoid sinulerectadione (4), along with three known isoprenoids, an unnamed norcembrene (5), sinularectin (6), and ineleganolide (7), and a known nitrogen-containing compound (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide (8), were isolated from an extract of the marine soft coral Sinularia erecta. The structure of sinularectin (6) was revised, too. Compounds 3, 4, and 8 exhibited inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 1, 2, and 8 displayed potent anti-inflammatory activity in fMLP/CB-stimulated human neutrophils. ? 2016 The American Chemical Society and American Society of Pharmacognosy.[SDGs]SDG3antineoplastic agent; cembranoid; cytochalasin B; elastase; formylmethionylleucylphenylalanine; idelalisib; ineleganolide; isoprenoid; n [2 (4 hydroxyphenyl)ethyl] 3 methyldodec 2 enamide; natural product; norcembrene; sinularectin; sinulerectadione; sinulerectol A; sinulerectol B; sinulerectol C; superoxide; unclassified drug; antiinflammatory agent; biological product; cyclooxygenase 2; diterpene; terpene; antiinflammatory activity; antineoplastic activity; Article; cancer cell line; carbon nuclear magnetic resonance; controlled study; coral; cytotoxicity; drug structure; enzyme release; heteronuclear multiple bond correlation; human; human cell; IC50; leukocyte activation; nuclear Overhauser effect; proton nuclear magnetic resonance; Sinularia erecta; solvent extraction; X ray crystallography; animal; Anthozoa; chemical structure; chemistry; drug screening; isolation and purification; macrophage; marine biology; metabolism; nuclear magnetic resonance; Animals; Anthozoa; Anti-Inflammatory Agents; Biological Products; Cyclooxygenase 2; Diterpenes; Drug Screening Assays, Antitumor; Humans; Macrophages; Marine Biology; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Terpenesjournal article10.1021/acs.jnatprod.5b011422-s2.0-84971449677WOS:000377150900015