Mendbayar K.Lo I.-W.Liaw C.-C.Lin Y.-C.Fazary A.E.Kuo Y.-C.Wang H.-J.Chiang B.H.Liou S.-S.Shen Y.-C.2019-07-112019-07-1120110018019Xhttps://scholars.lib.ntu.edu.tw/handle/123456789/413296Three new sesquiterpenes, schisansphenins A (1) and B (2) and (-)-£^-cuparenol (3), were isolated from an acetone extract of the fruits of Schisandra sphenanthera. The known compound 4 was isolated for the frist time from a natural source. The structures of the isolated compounds were elucidated through extensive spectroscopic analyses, particularly 2D-NMR experiments ( 1H, 1H-COSY, HMQC, HMBC, and NOESY). A plausible biogenetic pathway for schisansphenin B (2) is proposed. Compounds 2 and 3 significantly reduced activation of NF-AT and NF-£eB in the luciferase-reporter assay. Copyright ? 2011 Verlag Helvetica Chimica Acta AG, Z?rich, Switzerland.(-)-£^-CuparenolImmuno-modulating activitySchisandra sphenantheraSchisansphenins A and Bjournal article10.1002/hlca.2011002052-s2.0-83455258100https://www.scopus.com/inward/record.uri?eid=2-s2.0-83455258100&doi=10.1002%2fhlca.201100205&partnerID=40&md5=2018f6aeeb0a389a512ac43a05711f69