Guo I.-C.MENG-CHUN HUChung B.-C.2020-06-302020-06-3020031021-7770https://www.scopus.com/inward/record.uri?eid=2-s2.0-0242299680&doi=10.1159%2f000073524&partnerID=40&md5=91fc3924614660a164596aefb9a3807bhttps://scholars.lib.ntu.edu.tw/handle/123456789/507346Steroid hormones are important physiological regulators that control our glucose and salt balance, as well as sexual characteristics. The synthesis of steroid hormones is under tight control; disturbed secretion of steroids often leads to diseases. The mechanism controlling the secretion of steroids, namely steroidogenesis, has been the focus of intensive studies. CYP11A1 controls the first and rate-limiting step of steroid biosynthesis. It is expressed in the adrenal cortex and gonads, under the control of pituitary hormones, through the cAMP-signaling pathway. The promoter of the CYP11A1 gene contains sequences that bind to transcription factor SF-1, which plays an important role in the tissue-specific and hormonally regulated expression of steroidogenic genes. Detailed transcriptional analysis documents the importance of SF-1 in activating CYP11A1 in vitro and in vivo. Other factors like c-Jun are also involved. The assembly of various transcription factors forming protein-DNA complexes appears to be the key step in CYP11A1 transcription. Copyright ? 2003 National Science Council, ROC and S. Karger AG, Basel.Adrenal cortex; CYP11A1 transcription; Gonad; P450scc; SF-1; Steroid; Steroidogenesis[SDGs]SDG3cyclic AMP; cytochrome P450; cytochrome P450 11A1; hypophysis hormone; protein; protein c jun; steroid hormone; transcription factor; transcription factor sf1; unclassified drug; corticotropin; corticotropin releasing factor; cyclic AMP; cyclic AMP dependent protein kinase; cytochrome P450 CYP11A1; follitropin; luteinizing hormone; protein c jun; steroid hormone; steroidogenic factor 1; TATA binding protein; cholesterol monooxygenase (side chain cleaving); cyclic AMP dependent protein kinase; steroid; adrenal cortex; documentation; gene sequence; genetic analysis; gonad; hormonal regulation; hormone release; in vitro study; nonhuman; priority journal; protein DNA binding; protein expression; review; signal processing; steroidogenesis; tissue specificity; transcription regulation; adenohypophysis; adrenal gland; binding site; DNA flanking region; DNA protein complex; gene activation; gene activity; gene control; gene expression; human; hypothalamus; hypothalamus hypophysis adrenal system; ovary; placenta; promoter region; protein assembly; protein DNA interaction; signal transduction; TATA box; testis; transcription regulation; biosynthesis; gene expression regulation; genetic transcription; genetics; metabolism; physiology; second messenger; Cholesterol Side-Chain Cleavage Enzyme; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Promoter Regions (Genetics); Second Messenger Systems; Steroids; Transcription, GeneticReview10.1159/000073524145764612-s2.0-0242299680