Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazone-induced closure of the K(ATP) channel and insulin secretion in rats

TIEN-JYUN CHANGWEN-PIN CHENYang C.Lu P.-H.Liang Y.-C.Su M.-J.Lee S.-C.LEE-MING CHUANG2023-02-082023-02-082009-060012-186Xhttps://scholars.lib.ntu.edu.tw/handle/123456789/627739Rosiglitazone, an insulin sensitiser, not only improves insulin sensitivity but also enhances insulin secretory capacity by ameliorating gluco- and lipotoxicity in beta cells. Rosiglitazone can stimulate insulin secretion at basal and high glucose levels via a phosphatidylinositol 3-kinase (PI3K)-dependent pathway. We hypothesised that regulation of phosphorylation of the ATP-sensitive potassium (K(ATP)) channel might serve as a key step in the regulation of insulin secretion.enAMP-activated protein kinase; Insulin secretion; K-ATP channel; Serine phosphorylation; Rosiglitazone; BETA-CELL FUNCTION; SENSITIVE POTASSIUM CHANNELS; ACTIVATED RECEPTOR-GAMMA; PANCREATIC-ISLETS; PHOSPHATIDYLINOSITOL 3-KINASE; PEROXISOME PROLIFERATOR; TROGLITAZONE CS-045; SIGNALING PATHWAYS; DIABETES-MELLITUS; GENE-EXPRESSION[SDGs]SDG6Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazone-induced closure of the K(ATP) channel and insulin secretion in ratsjournal article10.1007/s00125-009-1337-4193578302-s2.0-67349132843WOS:000265684500018https://api.elsevier.com/content/abstract/scopus_id/67349132843