National Taiwan University Dept Chem EngnLin, Shih-YiShih-YiLinWayne, Huey-Herng SheuHuey-Herng SheuWayneChen, Wen-YinWen-YinChenLee, Fa-YauhFa-YauhLeeHuang, Ching-JangChing-JangHuang2006-11-142018-07-062006-11-142018-07-062005-01-18http://ntur.lib.ntu.edu.tw//handle/246246/2006111501222468Resistin, an adipose-derived polypeptide hormone, is proposed as a candidate of insulin resistance, although its roles in inhibiting adipogenesis & in inflammation have also been suggested. Liver cirrhosis is characterized by elevated circulating proinflammatory cytokines, including tumor necrosis factor- (TNF-), hyperinsulinemia & insulin resistance. The study aimed to examine resistin expression & its association with insulin & TNF- in a cirrhotic rat model using bile duct ligation (BDL). The BDL-induced cirrhotic rats showed significantly lower fat mass, insulin sensitivity & elevated plasma insulin & TNF- compared to sham animals. In addition, epididymal TNF- & resistin mRNA & protein levels were higher in cirrhotic rats. In normal control rats, in vivo insulin infusion & ex vivo administration of TNF- to cultured fat pads increased resistin gene expression significantly. These results implied that hyperinsulinemia & increased TNF- levels might upregulate adipose resistin gene in BDL-induced liver cirrhosis. Further study is necessary to document the role of resistin in metabolic abnormalities of liver cirrhosis.application/pdf261901 bytesapplication/pdfzh-TWHyperinsulinemiaLiver cirrhosisResistinTumor necrosis factor-journal articlehttp://ntur.lib.ntu.edu.tw/bitstream/246246/2006111501222468/1/3650.pdf