HAO-HUENG CHANGYEN-PING KUOSHIH-JUNG CHENGCHUN-PIN CHIANG2021-07-052021-07-0520091368-8375https://www.scopus.com/inward/record.uri?eid=2-s2.0-67549127813&doi=10.1016%2fj.oraloncology.2008.08.003&partnerID=40&md5=bac2e4261340452ddff0eb1ab0b2ad66https://scholars.lib.ntu.edu.tw/handle/123456789/569186This study used an immunohistochemical technique to examine the expression of BCL10 in 93 specimens of oral squamous cell carcinoma (OSCC) and 21 specimens of normal oral mucosa (NOM). We found a significant correlation between the higher mean BCL10 labeling index (LI) and OSCCs at the tongue, with larger tumor size, with positive lymph node metastasis, with more advanced clinical stages, or with recurrence (all p-values = 0.000). Positive lymph node metastasis (p = 0.044) and BCL10 LI > 50% (p = 0.037) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. The Kaplan-Meier curve showed that OSCC patients with a BCL10 LI > 50% had a significantly poorer cumulative survival than those with a BCL10 LI < 50% (log-rank test, p < 0.00001). We conclude that the BCL10 LI in OSCC samples can predict the progression of OSCCs and the survival of OSCC patients. ? 2008 Elsevier Ltd.[SDGs]SDG1[SDGs]SDG3protein bcl 10; adult; aged; article; cancer growth; cancer recurrence; cancer size; cancer staging; cancer survival; controlled study; correlation analysis; female; human; human tissue; immunohistochemistry; lymph node metastasis; major clinical study; male; mouth carcinoma; mouth mucosa; priority journal; prognosis; protein expression; squamous cell carcinoma; Taiwan; Adaptor Proteins, Signal Transducing; Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Case-Control Studies; Disease Progression; Female; Humans; Kaplan-Meier Estimate; Lymphatic Metastasis; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Prognosis; Taiwan; Tumor Markers, Biological; Young Adultjournal article10.1016/j.oraloncology.2008.08.003189524912-s2.0-67549127813