Ting M.CHIH-HSIEN WANGTsao C.-I.SHU-CHIEN HUANGNAI-HSIN CHINAI-KUAN CHOUYIH-SHARNG CHENSHOEI-SHEN WANG2021-05-072021-05-0720160041-1345https://www.scopus.com/inward/record.uri?eid=2-s2.0-84970028238&doi=10.1016%2fj.transproceed.2015.12.109&partnerID=40&md5=0796e119986e340e7bc1b80cc2fb1703https://scholars.lib.ntu.edu.tw/handle/123456789/560302Background: Acute fulminant myocarditis with intractable cardiogenic shock is a fatal condition; its only therapeutic option is mechanical circulatory support. The use of mechanical circulatory support, either extracorporeal membrane oxygenation (ECMO) or a ventricular assist device (VAD), serves as a bridge to recovery or as a bridge to transplantation. Objectives: The aim of this research was to advance our understanding of the outcome of heart transplantation under mechanical support for acute myocarditis. Two groups of patients were compared: those recovered without undergoing transplantation and those who underwent transplantation. Methods: We reviewed 134 patients experiencing acute myocarditis who required mechanical circulatory support (including ECMO and/or VAD) in our institute between 1994 and 2014. Demographic data, clinical characteristics, support duration, and outcome of individuals were retrospectively analyzed. Results: Patients taking part in this study were aged from 1 month to 70 years, with an average age of 28 years. The transplantation-free survival rate in adults was 54%. A total of 6 adult patients receive a heart transplant under ECMO/left VAD; 2 of these patients died of uncontrolled sepsis after the heart transplantation. The duration of mechanical support ranged from 10 to 130 days (average, 41 days). Conclusions: Mechanical circulatory support in patients with acute myocarditis proved to be effective. Approximately one half of all adult patients in this study experienced myocardium recovery under mechanical support, with only 5% undergoing a successful heart transplantation. In terms of patients who survived after heart transplantation, the mid-term and long-term outcomes are favorable.en[SDGs]SDG3acute disease; acute fulminant myocarditis; adolescent; adult; aged; Article; assisted circulation; brain death; cardiogenic shock; child; disease association; extracorporeal oxygenation; female; forward heart failure; heart transplantation; human; infant; major clinical study; male; myocarditis; priority journal; resuscitation; sepsis; survival rate; treatment duration; ventricular assist device; acute disease; complication; forecasting; heart assist device; heart transplantation; middle aged; myocarditis; procedures; retrospective study; Shock, Cardiogenic; Acute Disease; Adult; Extracorporeal Membrane Oxygenation; Female; Forecasting; Heart Transplantation; Heart-Assist Devices; Humans; Male; Middle Aged; Myocarditis; Retrospective Studies; Shock, Cardiogenicjournal article10.1016/j.transproceed.2015.12.109272347772-s2.0-84970028238