醫學檢驗暨生物技術學系CHEN, GRACE SHIA-HUYGRACE SHIA-HUYCHENCHEN, HUI-TINGHUI-TINGCHENLIN, SHWU-BINSHWU-BINLINCHERN, JI-WANGJI-WANGCHERN2008-12-082018-07-062008-12-082018-07-062007http://ntur.lib.ntu.edu.tw//handle/246246/89806Derivatives of indolo[2, 1-b]quinazolinone containing aminoalkylamino side chains were synthesized as specific DNA triplex stabilizing agents. The aminoalkylamino side chains are essential for triplex stabilization. The position-8 fluorine atom or a methyl group to the nitrogen adjacent to the planar core can enhance triplex stability by 6 degrees C and the effect is additive. Conformational analysis reveals that the orientation of the side chain underlies the ability of this compound to stabilize a DNA triplex. (c) 2006 Elsevier Ltd. All rights reserved.en-USDNA triplextriplex stabilizing agentstryptanthrinindolo[21-b]quinazolin-612-dionethermal denaturation