Yeh, Y PY PYehLuh, D LD LLuhSHU-HUI CHANGSuo, JJSuoChang, H JH JChangChen, Tony Hsiu HsiTony Hsiu HsiChen2020-05-212020-05-212005-070035-9203https://scholars.lib.ntu.edu.tw/handle/123456789/494241We aimed to assess whether tuberculin reactivity in adults is affected by bacille Calmette-Guerin (BCG) vaccination after 50 years of universal BCG vaccination with 80-95% coverage. A community-based study on tuberculin reactivity in 619 participants was conducted in February 2000 in Keelung city, Taiwan. Information on BCG vaccination policies and annual risk of infection (ARI) in the underlying population was extracted from consecutive national prevalence surveys relating to the period 1952-1997. Compared with the expected ARI estimate, the standardized morbidity ratio of positive tuberculin response for vaccination in infancy was 2.2 (95% CI 0.3-15.5) for those aged <10 years. The corresponding figures for older age groups ranged from 3.6 (95% CI 2.2-5.9) for those aged 10-12 years to 0.7 (95% CI 0.5-0.9) for those aged 57-67 years. This suggests that the effect of BCG vaccination on positive tuberculin response in adults aged >30 years is probably negligible irrespective of age at vaccination or revaccination and that the tuberculin skin test can be used to diagnose TB in control programmes in countries with moderate or high incidence of TB.entuberculosis; tuberculin skin test; BCG vaccine; RT23 tuberculin; Taiwan[SDGs]SDG3BCG vaccine; adolescent; adult; aged; article; BCG vaccination; child; city; community; controlled study; female; groups by age; health care policy; health survey; human; incidence; infancy; infant; infection risk; lung tuberculosis; major clinical study; male; medical information; morbidity; population research; prevalence; revaccination; standardization; Taiwan; tuberculin test; Adolescent; Adult; Age Distribution; Aged; BCG Vaccine; Child; Female; Humans; Male; Middle Aged; Risk Factors; Sex Distribution; Taiwan; Time Factors; Tuberculin; Tuberculin Test; Tuberculosis; Mycobacterium bovis BCGjournal article10.1016/j.trstmh.2005.03.001159108942-s2.0-18844399152WOS:000229714400007https://api.elsevier.com/content/abstract/scopus_id/18844399152