2009-08-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/674569摘要：根據世界衛生組織的報告， 老年性黃斑部病變( a g e - r e l a t e d m a c u l a r degeneration, AMD) 病變在2001 年就已經超過白內障成為造成視力障礙的最主要 原因，和糖尿病視網膜病變以及青光眼同樣成為老年人視力障礙的三大主要病變。 在台灣六十五歲以上的老人，罹患此病的盛行率也有10％並且有逐年增加的趨勢。 因為老年性黃斑部病變會造成視網膜病變，進而影響視力步入失明。近來對於此疾 病有諸多研究，在治療和手術上也有長足的進步，但是對於已經影響到視力甚至失 明的病患，在視力改善方面仍無有效方法，此外對此疾病的預防和保健至今尚很少 已經科學嚴謹證實很好的方法。在我們先期試驗(pilot study) 中，我們餵食具有 明目功效的數種不同傳統中草藥給視網膜病變的大鼠，初步結果發現枸杞萃取物有 減緩視網膜病變及視網膜功能下降的效果，因此我們很有興趣進一步研究奈米枸杞 對於視網膜病變大鼠的視網膜保護作用。在本實驗中我們將深入研究奈米枸杞在大 鼠模式視網膜病變的視網膜保護效果。此項計畫包含多個實驗項目，預估將持續進 行三年，第一年將建立視網膜病變的大鼠模式，並分析視網膜病變大鼠之視網膜功 能、視網膜組織病理等。自第二年起開始分組投予奈米枸杞，分為高、中、低劑量 ；視網膜退化前、視網膜退化後投予等，再評估各組大鼠視網膜功能、視網膜組織 病理等，最後再比較各組的實驗數據。本研究計畫之預期成果，有助於瞭解奈米枸 杞對於視網膜病變的視網膜保護作用如何，並以科學證據證明奈米枸杞是否可以成 為老年性黃斑部病變預防或是輔助治療的好選擇之一。<br> Abstract: According to the reports from WHO, the number of age-related macular　 degeneration (AMD) has exceeded that of cataract since 2001 as a major cause　of visual impairment in people in the world. AMD has kept up with diabetes　mellitus retinopathy and glaucoma as the leading three blinding illness. In　people, AMD causes retinopathy and reduced vision until totally blind. There　have been lots of researches recent years toward new techniques of surgical　operation to treat the illness, but there is still no satisfactory way to improve or　restore the patients’vision. The best we can do is to slow down the course of the　disease and preserve the rest of vision. In our pilot study on the effects of　 traditional Chinese herbs in rats with retinopathy, Lycium barbarum showed a　protective role in retinal morphology and electrophysiological function.　Therefore, we are interested to understand further the inhibitory effects of Lycium barbarum against retinal degeneration and ischemia.　In this study, we would like to investigate in details the inhibitory effects　and mechanism of Lycium barbarum against lightinduced retinal degeneration　(one standard AMD model) and retinal ischemia in rat models. The project is　comprised of many sections for a period of 3 years. In the 1st year, a　light-induced retinopathy and high intraocular pressure induced retinal ischemia　in rats will be established and characterized. Histolopathology and full-field　 electroretinogram (ERG) will be used to analyze the disease models. From 2nd　year, experiment procedures include investigation of the retinal function and histopathology in the rats taking nano Lycium barbarum. All experimental data will be analyzed and compared between different groups. The results of this study will allow us to understand the inhibitory effects of nano Lycium barbarum on retinopathy.　This information obtained from this study could be useful in understanding the　 therapeutic or preventive potential of the nano Lycium barbarum for those blinding and frustrating retinopathies.老年性黃斑部病變視網膜病變奈米枸杞Age-related macular degenerationretinopathynano/submicron Lycium