Hung, Kuo ChiKuo ChiHungWang, Shih WenShih WenWangYUN HSIAMUH-SHY CHENTsai, Chia YingChia YingTsaiTZYY-CHANG HO2023-03-212023-03-212020-08-011755375Xhttps://scholars.lib.ntu.edu.tw/handle/123456789/629512Purpose: We investigated the natural course of the intraretinal hyperreflective (IRH) sign after macular haemorrhage (MHE) absorption in eyes with pathologic myopia. Methods: This prospective observational cohort study evaluated 28 patients with pathologic myopia and MHE. The eyes were categorized into IRH and non-IRH sign groups according to IRH sign development. All eyes were evaluated; follow-up visits were scheduled at 1, 3, 6, 12 and 24 months after MHE absorption. Results: Of 28 patients (14 eyes each in the IRH and non-IRH groups), nine (32.1%) were men and 19 (67.9%) were women. The average age (mean ± SD) was 46.64 ± 11.92 versus 52.71 ± 12.19 years in the IRH and non-IRH groups. The IRH sign coincided with the MHE invasion site. The sign persisted for the entire follow-up period in all but two eyes, in which it disappeared at 12 and 24 months, respectively. Maximal MHE thickness was significantly greater in the IRH sign group (162.9 ± 67.84 versus 104.2 ± 32.34 μm, p = 0.013). The mean logarithm of the minimum angle of resolution visual acuity was significantly better in the non-IRH sign group at 12 (p = 0.029) and 24 (p = 0.033) months. The incidence of myopic traction maculopathies (MTM) was significantly higher in the IRH (57.1%) than in the non-IRH sign group (14.3%; p = 0.046). Conclusion: The IRH sign can develop after MHE in pathologic myopia and can remain stable long after MHE absorption; furthermore, it is predictive of future MTM.enintraretinal hyperreflective sign | macular haemorrhage | myopic macular maculopathies | optical coherence tomography | pathologic myopia[SDGs]SDG3journal article10.1111/aos.14332318083002-s2.0-85076168598WOS:000500764400001https://api.elsevier.com/content/abstract/scopus_id/85076168598