Wei T.C.Yu S.C.PO-HUANG LEEHsu S.C.2020-11-192020-11-1919930929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027623362&partnerID=40&md5=f27223d0b59f4b67cc0c01d99370cd60https://scholars.lib.ntu.edu.tw/handle/123456789/521668Ninety-one patients were identified as having carcinoma arising from the ampulla of Vater. Radical pancreaticoduodenectomy, using either a standard or pylorus-preserving method, was performed in 69 consecutive patients over a 30-year period. Frequent clinical findings included jaundice (84%), a weight loss of more than 10% of the body weight (75%), abdominal pain (59%), chills and fever (52%), pruritus (48%) and a palpable gallbladder (38%). Acute pancreatitis was present in 10%. Postoperative mortality was 11.6%. Surgical mortality was 23.1% from 1962 to 1971 and 12.5% from 1972 to 1981, but was reduced to 6.3% from 1982 to 1991. Surgical mortality was primarily due to pancreaticojejunostomy leaks. The five-year survival rate was 52% and the 10-year rate was 50%. Radical pancreaticoduodenectomy for ampullary carcinoma has a low mortality and should remain the procedure of choice for ampullary carcinoma.[SDGs]SDG3adult; aged; article; bile duct tumor; carcinoma; female; human; male; middle aged; mortality; pancreaticoduodenectomy; retrospective study; survival; Vater papilla; Adult; Aged; Aged, 80 and over; Ampulla of Vater; Carcinoma; Common Bile Duct Neoplasms; Female; Humans; Male; Middle Aged; Pancreaticoduodenectomy; Retrospective Studies; Survival Analysisjournal article79044992-s2.0-0027623362