Machiela, Mitchell JMitchell JMachielaZhou, WeiyinWeiyinZhouKarlins, EricEricKarlinsSampson, Joshua NJoshua NSampsonFreedman, Neal DNeal DFreedmanYang, QiQiYangHicks, BelyndaBelyndaHicksDagnall, CaseyCaseyDagnallHautman, ChristopherChristopherHautmanJacobs, Kevin BKevin BJacobsAbnet, Christian CChristian CAbnetAldrich, Melinda CMelinda CAldrichAmos, ChristopherChristopherAmosAmundadottir, Laufey TLaufey TAmundadottirArslan, Alan AAlan AArslanBeane-Freeman, Laura ELaura EBeane-FreemanBerndt, Sonja ISonja IBerndtBlack, AmandaAmandaBlackBlot, William JWilliam JBlotBock, Cathryn HCathryn HBockBracci, Paige MPaige MBracciBrinton, Louise ALouise ABrintonBueno-de-Mesquita, H BasH BasBueno-de-MesquitaBurdett, LaurieLaurieBurdettBuring, Julie EJulie EBuringButler, Mary AMary AButlerCanzian, FedericoFedericoCanzianCarreón, TaniaTaniaCarreónChaffee, Kari GKari GChaffeeChang, I-ShouI-ShouChangChatterjee, NilanjanNilanjanChatterjeeChen, ChuChuChenChen, ConstanceConstanceChenChen, KexinKexinChenChung, Charles CCharles CChungCook, Linda SLinda SCookCrous Bou, MartaMartaCrous BouCullen, MichaelMichaelCullenDavis, Faith GFaith GDavisDe Vivo, ImmaculataImmaculataDe VivoDing, TiTiDingDoherty, JenniferJenniferDohertyDuell, Eric JEric JDuellEpstein, Caroline GCaroline GEpsteinFan, Jin-HuJin-HuFanFigueroa, Jonine DJonine DFigueroaFraumeni, Joseph FJoseph FFraumeniFriedenreich, Christine MChristine MFriedenreichFuchs, Charles SCharles SFuchsGallinger, StevenStevenGallingerGao, Yu-TangYu-TangGaoGapstur, Susan MSusan MGapsturGarcia-Closas, MontserratMontserratGarcia-ClosasGaudet, Mia MMia MGaudetGaziano, J MichaelJ MichaelGazianoGiles, Graham GGraham GGilesGillanders, Elizabeth MElizabeth MGillandersGiovannucci, Edward LEdward LGiovannucciGoldin, LynnLynnGoldinGoldstein, Alisa MAlisa MGoldsteinHaiman, Christopher AChristopher AHaimanHallmans, GoranGoranHallmansHankinson, Susan ESusan EHankinsonHarris, Curtis CCurtis CHarrisHenriksson, RogerRogerHenrikssonHolly, Elizabeth AElizabeth AHollyHong, Yun-ChulYun-ChulHongHoover, Robert NRobert NHooverHsiung, Chao AChao AHsiungHu, NanNanHuHu, WeiWeiHuHunter, David JDavid JHunterHutchinson, AmyAmyHutchinsonJenab, MazdaMazdaJenabJohansen, ChristofferChristofferJohansenKhaw, Kay-TeeKay-TeeKhawKim, Hee NamHee NamKimKim, Yeul HongYeul HongKimKim, Young TaeYoung TaeKimKlein, Alison PAlison PKleinKlein, RobertRobertKleinKoh, Woon-PuayWoon-PuayKohKolonel, Laurence NLaurence NKolonelKooperberg, CharlesCharlesKooperbergKraft, PeterPeterKraftKrogh, VittorioVittorioKroghKurtz, Robert CRobert CKurtzLaCroix, AndreaAndreaLaCroixLan, QingQingLanLandi, Maria TeresaMaria TeresaLandiMarchand, Loic LeLoic LeMarchandLi, DonghuiDonghuiLiLiang, XiaolinXiaolinLiangLiao, Linda MLinda MLiaoLin, DongxinDongxinLinLiu, JianjunJianjunLiuLissowska, JolantaJolantaLissowskaLu, LingengLingengLuMagliocco, Anthony MAnthony MMaglioccoMalats, NuriaNuriaMalatsMatsuo, KeitaroKeitaroMatsuoMcNeill, Lorna HLorna HMcNeillMcWilliams, Robert RRobert RMcWilliamsMelin, Beatrice SBeatrice SMelinMirabello, LisaLisaMirabelloMoore, LeeLeeMooreOlson, Sara HSara HOlsonOrlow, IreneIreneOrlowPark, Jae YongJae YongParkPatiño-Garcia, AnaAnaPatiño-GarciaPeplonska, BeataBeataPeplonskaPeters, UlrikeUlrikePetersPetersen, Gloria MGloria MPetersenPooler, LoreallLoreallPoolerPrescott, JenniferJenniferPrescottProkunina-Olsson, LudmilaLudmilaProkunina-OlssonPurdue, Mark PMark PPurdueQiao, You-LinYou-LinQiaoRajaraman, PreethaPreethaRajaramanReal, Francisco XFrancisco XRealRiboli, ElioElioRiboliRisch, Harvey AHarvey ARischRodriguez-Santiago, BenjaminBenjaminRodriguez-SantiagoRuder, Avima MAvima MRuderSavage, Sharon ASharon ASavageSchumacher, FredrickFredrickSchumacherSchwartz, Ann GAnn GSchwartzSchwartz, Kendra LKendra LSchwartzSeow, AdelineAdelineSeowWendy Setiawan, VeronicaVeronicaWendy SetiawanSeveri, GianlucaGianlucaSeveriShen, HongbingHongbingShenSheng, XinXinShengShin, Min-HoMin-HoShinShu, Xiao-OuXiao-OuShuSilverman, Debra TDebra TSilvermanSpitz, Margaret RMargaret RSpitzStevens, Victoria LVictoria LStevensStolzenberg-Solomon, RachaelRachaelStolzenberg-SolomonStram, DanielDanielStramTang, Ze-ZhongZe-ZhongTangTaylor, Philip RPhilip RTaylorTeras, Lauren RLauren RTerasTobias, Geoffrey SGeoffrey STobiasVan Den Berg, DavidDavidVan Den BergVisvanathan, KalaKalaVisvanathanWacholder, SholomSholomWacholderWang, Jiu-CunJiu-CunWangWang, ZhaomingZhaomingWangWentzensen, NicolasNicolasWentzensenWheeler, WilliamWilliamWheelerWhite, EmilyEmilyWhiteWiencke, John KJohn KWienckeWolpin, Brian MBrian MWolpinWong, Maria PikMaria PikWongWu, ChenChenWuWu, TangchunTangchunWuWu, XifengXifengWuWu, Yi-LongYi-LongWuWunder, Jay SJay SWunderXia, LucyLucyXiaYang, Hannah PHannah PYangPAN-CHYR YANGYu, KaiKaiYuZanetti, Krista AKrista AZanettiZeleniuch-Jacquotte, AnneAnneZeleniuch-JacquotteZheng, WeiWeiZhengZhou, BaosenBaosenZhouZiegler, Regina GRegina GZieglerPerez-Jurado, Luis ALuis APerez-JuradoCaporaso, Neil ENeil ECaporasoRothman, NathanielNathanielRothmanTucker, MargaretMargaretTuckerDean, Michael CMichael CDeanYeager, MeredithMeredithYeagerChanock, Stephen JStephen JChanock2023-01-092023-01-092016-06-132041-1723https://scholars.lib.ntu.edu.tw/handle/123456789/627038To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases.enDETECTABLE CLONAL MOSAICISM; SOMATIC MOSAICISM; BLOOD; METHYLATION; HEMATOPOIESIS; ANEUPLOIDIES; GENOME; RISK[SDGs]SDG3journal article10.1038/ncomms11843272917972-s2.0-84974736225WOS:000378387800001https://scholars.lib.ntu.edu.tw/handle/123456789/523475