2017-02-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/644960摘要：肝癌為相當惡性之腫瘤,每年全世界有超過 700,000 名病人被確診罹患肝癌,多數患者臨床上 並無顯著早期徵兆,因而就醫診斷時可能皆已肝癌晚期,不僅肝功能狀況不佳使得治療手段的選擇 有所 侷限,亦降低了腫瘤之治療有效性,五年存活率僅 10%,因此發展一個有效的肝癌治療方法有 迫切的需要。超音波對比劑為一種可被生物分解的微氣泡,具有增強聲場散射信號之作用,超音波影像技術 隨著超音波對比劑的發展改善了成像的空間解析度及影像動態範圍。在臨床應用上除了傳統心血管 疾病與癌症之診斷,近來更被應用於促進藥物釋放與提升化學治療效率上。博信生物科技之技術提 供了一安全有效之微氣泡平台,相較目前國際產品提供了更小的微氣泡粒徑與最佳化之濃度,能在 較低的注射劑量下有效提升產品之效價與影像解析度,且能減少慣性穴蝕的發生,增加使用之安全 性。本計畫預計提出肝癌治療之新治療策略,以博信生物科技公司所研發之微氣泡與治療用超音波 系統,藉由超音波與超音波對比劑間的交互作用,提升局部腫瘤區域之通透性,同時降低全身性之 化療毒性,將此技術應用於小動物肝腫瘤之治療,預期:(1)提升傳統化療舊藥之效率;(2)合併肝腫 瘤燒灼治療,設計有效之新式肝癌治療流程。<br> Abstract: Hepatocellular carcinoma (HCC) is a malignant cancer and the third leading cause ofcancer mortality worldwide. The majority of patients experience no significant earlysigns, and thus once the diagnosis of HCC is confirmed, course of the disease hasentered the late stage. The poor liver function and the advanced disease hinder theselection of treatment options and lower the efficiency of cancer treatment,contributing to a relatively low reported 5-year survival rate of approximately 10%.Ultrasound contrast agents (UCAs), as biodegradable microbubbles, have the ability ofenhancing ultrasound scattering signals. The development of UCAs improves thespatial resolution and dynamic range of ultrasound imaging techniques. Conventionalclinical applications include diagnosis of cardiovascular diseases and tumor diagnosis.Recently, UCAs are applied to enhace the drug delivery. Trust Bio-sononics, Inc.provides a safe and effective microbubble platform (USpheresTM) which possessessmaller size distribution and more optimized concentration compared to the currentcommercialized UCAs, enhancing the potency and image resolution under lower givendose. Furthermore, the small size of USpheresTM series reduces the inertial cavitation,improving in vivo safety of UCAs.The aim of this study is to propose a new HCC treatment strategy by using theUSpheresTM microbubbles and ultrasound treatment system estabilished byBio-sononics, Inc. The interactions of ultrasound and microbubbles enhance the localpermeability of tumor, and reduce the systematic toxicity arised from chemotherapy.Applying this technique on small animal HCC model, it is anticipated to improve thetreatment efficiency of the current clinically used chemotherapeutic drugs. Futhermore,combining with radio-frequency ablation, a new and efficient HCC treatment strategyis designed.