國立臺灣大學電機工程學系暨研究所鍾孝文2006-07-252018-07-062006-07-252018-07-062002-07-31http://ntur.lib.ntu.edu.tw//handle/246246/7900本計畫之目的在於發展影像分析技 術，用於高空間時間解析度之腦脊髓液動 態流速分析，以估計腦脊髓液產生率。十 九位受試者參與實驗，掃瞄影像後以相關 係數分佈圖及區域成長法自動選取大腦導 水管區域進行腦脊髓液產生率自動計算。 所求得健康受試者腦脊髓液產生率約為 332±137 ul/min，與侵入式量測法結果相 符。若不以本計畫方式自動量測，則操作 者所引起之平均誤差高達24.1% (5.8~59.2%)。吾人結論相位對比磁振造影 經過解析度最佳化以及分析自動化之後， 應可使用於非侵入式腦脊髓液產生率之臨 床評估。The purpose of this project was to determine the CSF production rate in healthy adults using cine phase-contrast MR imaging with high temporal and spatial resolutions plus dedicated image analysis software. 19 healthy adults were imaged. Correlation coefficient maps were generated based on pixel-by-pixel analysis of temporal flow patterns, from which the cross-sectional aqueduct area was defined using a region-growing algorithm. The CSF production rates were calculated using numerical integration. Operator-dependent imprecision and effects of temporal resolution were investigated. The automatic segmentation approach yielded average CSF production rate of 332±137 ul/min, in good agreement with literature values obtained with invasive ventriculolumbar perfusion measurements. Mean operator imprecision was 24.1% (5.8~59.2%). Phase-contrast MR imaging with sufficient temporal and spatial resolution is potentially an effective approach for measuring CSF production rate on a routine basis.application/pdf184885 bytesapplication/pdfzh-TW國立臺灣大學電機工程學系暨研究所腦脊髓液產生率磁振造影相 位對比CSF production ratemagnetic resonance imagingphase contrastreporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/7900/1/902314B002256.pdf