Lee, Kuan-YiKuan-YiLeeLiu, Chia-MingChia-MingLiuLI-HAN CHENLee, Chien-YuehChien-YuehLeeTZU-PIN LUChuang, Li-LingLi-LingChuangLIANG-CHUAN LAI2023-03-212023-03-212023-03-101475-2867https://scholars.lib.ntu.edu.tw/handle/123456789/629500Breast cancer is a prevalent disease in women, with high prevalence worldwide. The hypoxic microenvironment of solid tumors develops during the progress of carcinogenesis and leads to greater malignancy and treatment resistance. Recently, accumulating evidence indicates that non-coding RNAs, such as circular RNAs (circRNAs), play a pivotal role in altering cellular functions. However, the underlying mechanisms of circRNAs in breast cancer are still unclear. Therefore, the purpose of this study was to investigate the role of a tumor-suppressive circRNA, circAAGAB, in breast cancer by assuming down-regulation of circAAGAB under hypoxia and the properties of a tumor suppressor.enBreast cancerHypoxiaRadiosensitivityTumor suppressorcircAAGABmiRNA spongep38 MAPK[SDGs]SDG3journal article10.1186/s12935-023-02891-0368993542-s2.0-85149942403https://api.elsevier.com/content/abstract/scopus_id/85149942403