S.-H. WangC.-W. WeiS.-H. JeePAI-CHI LISHIOU-HWA JEE2018-09-102018-09-102009-01http://scholars.lib.ntu.edu.tw/handle/123456789/352554Plasmonic photothermal therapy is a new cancer thermotherapy method based on surface plasmon resonance of nanoparticles. It is important to measure the temperature during thermotherapy for safety and efficacy. In this study, we apply a photoacoustic (PA) method for real-time, non-invasive temperature measurements. In particular, this method can be effectively combined with a photothermal therapy system that we developed in parallel. The method is based on the fact that the PA pressure amplitude is linearly related to temperature. To explore its potential, a home-made, 20 MHz PA transducer was used, in which an optical fiber was inserted in its center for emitting laser pulses while the PA signal was simultaneously detected. Continuous wave (CW) laser was used to heat the subject, including both phantoms and mice. The temperature of the region of interest was also measured by a fine-needle thermal couple. Results show that the temperature was linearly proportional to the PA signal with good correlation with the CW laser irradiation. The in vivo study also demonstrated potential of this technique. ? 2009 SPIE.Laser; Photoacoustics; Plasmonic photothermal therapy; Surface plasmon resonance; Temperature measurement[SDGs]SDG3Continuous waves; CW-laser; Good correlations; In-vivo; Linearly proportional; Non-invasive; Photoacoustics; Photothermal therapy; Plasmonic photothermal therapy; Pressure amplitudes; Region of interest; Thermal couple; Thermotherapy; Acoustic waves; Lasers; Optical fibers; Photoacoustic effect; Photons; Physical therapy; Planers; Plasmons; Pulsed laser applications; Surface plasmon resonance; Temperature measuring instruments; Ultrasonic applications; Ultrasonic imaging; Ultrasonics; Temperature measurementconference paper10.1117/12.8099732-s2.0-66249134936