李嘉哲2006-07-262018-07-112006-07-262018-07-111999http://ntur.lib.ntu.edu.tw//handle/246246/23414高再發率以及低長期存活率一直是肝 細胞癌臨床上面臨的問題。肝局部切除 後，肝細胞生長因子、介白質6 、轉形生長 因子、表皮生長因子促成肝的再生。我們 檢驗了40 例手術切除之肝細胞癌的標本， 測定上述生長因子的受體是否在肝細胞癌 有表現以及它們的表現是否與肝細胞癌的 再發有關。我們發現大部分的肝細胞癌都 有表現上述生長因子的受體。受體的量與 癌大小無關。肝細胞的再發與受體的量， 肝硬化的有無，病人年齡、性別，HBsAg 及Anti-HCV 無關。在71%病人，介白質6 受體在正常肝細胞與肝細胞癌大小不同。 總結為肝細胞癌有表現與肝再生有生長關 因子之受體。肝細胞癌再發與受體之表現 無關。肝細胞癌生長之主要控制機轉可能 與肝再生控制機轉不同。high recurrence rate and poor long term survival of patients with hepatocellular carcinoma (HCC) receiving operation remains a serious clinical problem. After partial hepatectomy, hepatocyte growth factor, interlukin-6,transforming growth factor and epidermal growth factor contribute to the regeneration of liver. We examined 40 surgical resected HCC samples to determin whether the receptors of above growth factors were expressed in HCC and how they correlated with tumor recurrence.We found that most of the HCC did express receptors for growth factors.The amount of receptors did not correlate with the tumor size.The recurrence of HCC did not correlate with the amount of receptors in tumor tissue,age,sex, HBsAg,Anti-HCV and presence of liver cirrhosis.There is size difference of interleukin 6 receptor between nontumor and tumor tissue in 71%cases. In conclusion,HCC expresses receptors for growth factors related to liver regeneration.The recurrence of HCC did not related to expression of growth factor receptors.The growth of HCC is probably mainly controlled by different mechanisms from liver regeneration.application/pdf25552 bytesapplication/pdfzh-TW國立臺灣大學醫學院內科肝細胞癌肝細胞生長因子介白質6表皮生長因子受體hepatocellular carcinomahepatocyte growth factorinterleukin 6transforming growth factorepidermal growth factorreceptorreporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/23414/1/882314B002192.pdf