Yuan HHSIU-WEI CHENGMears L.L.EHuang RSu RQi WHe ZValtiner M.2022-12-142022-12-14202107437463https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120053318&doi=10.1021%2facs.langmuir.1c01581&partnerID=40&md5=b78856b57d54c41c77d4d0af7d78c43ahttps://scholars.lib.ntu.edu.tw/handle/123456789/626299Osteoarthritis is a prevalent degenerative joint disease characterized by progressive articular cartilage loss and destruction. The resultant increase in friction causes severe pain. The collagen I matrix (COL I) has been used clinically for cartilage repair; however, how COL I acts at cartilage surfaces is unclear. Here, we studied adsorption and lubrication of synovial fluid components, albumin, γ-globulin, and the phospholipid DPPC, on COL I under physiological conditions using surface plasmon resonance and an in situ sensing surface force apparatus. Our results revealed COL I had poor lubrication ability, a fairly high coefficient of friction (COF, μ = 0.651 ± 0.013), and surface damage under a 7 mN load. DPPC formed an improved lubricating layer on COL I (μ = 0.072 ± 0.016). In sharp contrast, albumin and γ-globulin exhibited poor lubrication with an order of magnitude higher COF but still provided benefits by protecting COL I from wear. Hence, DPPC on COL I may help optimize COL I implantation design. © 2021 The Authors. Published by American Chemical Society.Cartilage; Collagen; Friction; Phospholipids; Surface plasmon resonance; Wear of materials; Wear resistance; Anchorings; Articular cartilages; Cartilage repair; Cartilage surfaces; Collagen I; Degenerative joint disease; Lubrication /; matrix; Synovial fluid; γ-Globulins; Lubrication; collagen type 1; lipid; articular cartilage; friction; lubrication; Cartilage, Articular; Collagen Type I; Friction; Lipids; Lubricationjournal article10.1021/acs.langmuir.1c01581347880362-s2.0-85120053318