Bacillus coagulans 198 and L-glutamine in combination attenuated intestinal mucositis in a 5-FU-induced BALB/c mouse model via modulation of gut microbial community structure and diversity

Chen, Wei-JenWei-JenChenShen, Siou-RuSiou-RuShenHsu, Wei-HsuanWei-HsuanHsuLee, Bao-HongBao-HongLeeWei, Yu-ShanYu-ShanWeiChu, Hui-FangHui-FangChuTseng, Ming-ChungMing-ChungTsengShen, Tang-LongTang-LongShen2025-06-032025-06-032025-03-2710219498https://www.scopus.com/record/display.uri?eid=2-s2.0-105001825869&origin=resultslisthttps://scholars.lib.ntu.edu.tw/handle/123456789/7298635-Fluorouracil (5-FU) disrupts intestinal cells and causes dysbiosis in the gut microbiota. This study explores the potential of Bacillus coagulans-198 (BC198) to mitigate gut microbiota imbalance and mucositis caused by 5-fluorouracil. L-glutamine is used to alleviate mucositis, and this study found that BC198 exhibits protective effects on the gut, including maintaining a healthy microbiota and reducing intestinal inflammation, regardless of whether L-glutamine is used in combination. Therefore, it can help reduce the deterioration of the gut environment caused by 5-fluorouracil. BC198 can be provided to cancer patients to prevent severe side effects, thereby improving their treatment outcomes and nutritional status.false5-Fluorouracil (5-FU)Bacillus coagulans-198 (BC198)Intestinal inflammationMicrobiotaMucositis[SDGs]SDG3Bacillus coagulans 198 and L-glutamine in combination attenuated intestinal mucositis in a 5-FU-induced BALB/c mouse model via modulation of gut microbial community structure and diversityjournal article10.38212/2224-6614.35352-s2.0-105001825869