Tsou T.-P.Tan B.-F.Chang H.-Y.Chen W.-C.Huang Y.-P.Lai C.-Y.Chao Y.-N.Wei S.-H.Hung M.-N.Hsu L.-C.CHUN-YI LUPEI-LAN SHAOMu J.-J.LUAN-YIN CHANGLiu M.-T.LI-MIN HUANG2020-12-152020-12-1520121080-6040https://www.scopus.com/inward/record.uri?eid=2-s2.0-84867876838&doi=10.3201%2feid1811.120629&partnerID=40&md5=9be9c668e573420ad6b183d39e9c187ahttps://scholars.lib.ntu.edu.tw/handle/123456789/525562In 2011, a large community outbreak of human adenovirus (HAdV) in Taiwan was detected by a nationwide surveillance system. The epidemic lasted from week 11 through week 41 of 2011 (March 14-October 16, 2011). Although HAdV-3 was the predominant strain detected (74%), an abrupt increase in the percentage of infections caused by HAdV-7 occurred, from 0.3% in 2008-2010 to 10% in 2011. Clinical information was collected for 202 inpatients infected with HAdV; 31 (15.2%) had severe infection that required intensive care, and 7 of those patients died. HAdV-7 accounted for 10%, 12%, and 41% of infections among outpatients, inpatients with nonsevere infection, and inpatients with severe infection, respectively (p<0.01). The HAdV-7 strain detected in this outbreak is identical to a strain recently reported in the People's Republic of China (HAdV7-HZ/SHX/CHN/2009). Absence of circulating HAdV-7 in previous years and introduction of an emerging strain are 2 factors that caused this outbreak.[SDGs]SDG3antiinfective agent; immunoglobulin; adolescent; adult; animal cell; article; child; death; disease severity; disease surveillance; epidemic; extracorporeal oxygenation; female; human; Human adenovirus; human adenovirus infection; human cell; infant; major clinical study; male; molecular diagnosis; nonhuman; nucleotide sequence; phylogeny; polymerase chain reaction; preschool child; prognosis; retrospective study; school child; Taiwan; virus identification; virus isolation; virus typing; Adenovirus Infections, Human; Adenoviruses, Human; Adolescent; Capsid Proteins; Child; Child, Preschool; Disease Outbreaks; Humans; Infant; Infant, Newborn; Inpatients; Outpatients; Phylogeny; Population Surveillance; Prognosis; Taiwanjournal article10.3201/eid1811.120629230926022-s2.0-84867876838