Chappell M.Payne S.STEPHEN JOHN PAYNE2022-05-242022-05-242016https://www.scopus.com/inward/record.uri?eid=2-s2.0-85027265852&doi=10.1007%2f978-3-319-26197-3_5&partnerID=40&md5=86f280be65fd1d9cfc88d28173100bc1https://scholars.lib.ntu.edu.tw/handle/123456789/611771In this chapter we meet a general method for the treatment of the body as a whole system in which the behaviour of substances can by described mathematically. We will introduce compartmental models built around the ADME principles to write down and to solve differential equations for simple pharmacokinetics problems. We will also apply the same principles to tracer kinetics to measure the delivery of a contrast agent to tissue in medical imaging applications. ? Springer International Publishing Switzerland 2016.book part10.1007/978-3-319-26197-3_52-s2.0-85027265852