Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice

Dalaijamts, ChimeddulamChimeddulamDalaijamtsCichocki, Joseph AJoseph ACichockiYU-SYUAN LUORusyn, IvanIvanRusynChiu, Weihsueh AWeihsueh AChiu2023-04-272023-04-272018-08-010041-008Xhttps://scholars.lib.ntu.edu.tw/handle/123456789/630655Perchloroethylene (perc) induced target organ toxicity has been associated with tissue-specific metabolic pathways. Previous physiologically-based pharmacokinetic (PBPK) modeling of perc accurately predicted oxidative metabolites but suggested the need to better characterize glutathione (GSH) conjugation as well as toxicokinetic uncertainty and variability.enBayesian analysis; Glutathione conjugation; Oxidative metabolism; Physiologically based pharmacokinetic (PBPK) model; Risk assessment; TetrachloroethyleneIncorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in micejournal article10.1016/j.taap.2018.05.033298570802-s2.0-85048476414WOS:000436899300015https://api.elsevier.com/content/abstract/scopus_id/85048476414