Wen W.-H.MEI-HWEI CHANGHONG-YUAN HSUYEN-HSUAN NIHUEY-LING CHEN2021-01-042021-01-0420040022-3476https://www.scopus.com/inward/record.uri?eid=2-s2.0-1542721034&doi=10.1016%2fj.jpeds.2003.11.022&partnerID=40&md5=3d6982bbda24073b0aaeaabace9abf67https://scholars.lib.ntu.edu.tw/handle/123456789/537111We prospectively followed 426 children with chronic hepatitis B virus infection. During 6250 person-years, 2 boys developed hepatocellular carcinoma, with an incidence of 32 per 100,000 person-years. Both had e antigen seroconversion in early childhood and cirrhosis. Early e antigen seroconversion and/or cirrhosis may be risk factors for hepatocellular carcinoma.[SDGs]SDG3adolescent; adult; article; child; controlled study; disease course; female; hepatitis B; Hepatitis B virus; human; incidence; liver cell carcinoma; liver cirrhosis; major clinical study; male; priority journal; risk factor; seroconversionjournal article10.1016/j.jpeds.2003.11.022150019562-s2.0-1542721034