Alexander Pinky SteffiRamachandran BalajiYING-CHIH LIAONarendhar Chandrasekar2024-07-172024-07-172023-01-0197898119943649789811994371https://www.scopus.com/record/display.uri?eid=2-s2.0-85197081834&origin=resultslisthttps://scholars.lib.ntu.edu.tw/handle/123456789/719885Multidisciplinary initiatives in the area of nanomedicine for biological applications have made significant progress toward overcoming typical constraints of conventional drug delivery, which including poor biomagnification, wettability, and non-specific bioavailability and targeting. For better bioanalytical performance, a novel class of metal nanostructures with a distinctive dendritic-shaped morphology has been developed. Because of their specific physicochemical, refractive, and electrical features, branched metal nanoparticles or metal nanodendrites are thought to have intriguing qualities for biological applications. Owing to their three-dimensional (3D) large surface area, nanodendrites may improve the loading efficiency of bioactive chemicals and can selectively transport their cargo to tumor cells utilizing their stimuli-responsive capabilities. Nanodendrites may evade detection and removal by bioimages because to their propensity to concentrate enough inside cells. Furthermore, active targeting ligands like antibodies and proteins may be added to these therapeutic nanodendrites to improve tumor targeting, resulting in a multipurpose nanoplatform with customizable methods. Nanodendrites are especially exceptional and extremely interesting in their architectural layout between metal nanoparticles with additional structural morphologies including such nanoplates, nanorods, nanocages, nanoprisms, nanostars, nanodumbbells, etc., due to their own threedimensional (3D) morphology to numerous dense clusters of branches of highly permeable surface features. This chapter contains a concentrated examination of metallic nanodendrites for potential bioanalytical uses. In consideration of their production techniques, we have emphasized the different kinds and characteristics of metallic nanodendrites. Following that, current developments in the production of dendritic-shaped nanoparticles with significant photothermal and stimuli-responsive medicinal functions are reviewed in depth. Finally, we present exciting potential for improving bioanalytical applications in particular for cancer treatment by developing metallic nanodendrites.falseBioanalytical applicationsMetallic nanoparticlesNanodendritesTherapeutic drug deliverybook part10.1007/978-981-19-9437-1_322-s2.0-85197081834