YU-WEN TIENChien, Hung-JenHung-JenChienChiang, Tsai-ChenTsai-ChenChiangChung, Mei-HsinMei-HsinChungCHIH-YUAN LEEPeng, Shih-JungShih-JungPengCHIEN-CHIA CHENChou, Ya-HsienYa-HsienChouHsiao, Fu-TingFu-TingHsiaoYUNG-MING JENGTang, Shiue-ChengShiue-ChengTang2021-11-262021-11-262021-100012186Xhttps://scholars.lib.ntu.edu.tw/handle/123456789/587901Islets are thought to be stably present in the adult human pancreas to maintain glucose homeostasis. However, identification of the pancreatic intraepithelial neoplasia (PanIN)-islet complex in mice and the presence of PanIN lesions in adult humans suggest that similar remodelling of islet structure and environment may occur in the human pancreas. To identify islet remodelling in a clinically related setting, we examine human donor pancreases with 3D histology to detect and characterise the human PanIN-islet complex.en3D pancreatic histology; Human islet; Intra-islet duct; Islet aggregation; Islet cell neogenesis; Pancreatic intraepithelial neoplasiajournal article10.1007/s00125-021-05504-5342725812-s2.0-85111847387https://scholars.lib.ntu.edu.tw/handle/123456789/577815