BOR-SHIUNN LEETsai H.-Y.YI-LING TSAILan W.-H.CHUN-PIN LIN2021-07-062021-07-0620050287-4547https://www.scopus.com/inward/record.uri?eid=2-s2.0-33644824204&doi=10.4012%2fdmj.24.562&partnerID=40&md5=dba011a5a1bfe2c054c7c31f0be645dfhttps://scholars.lib.ntu.edu.tw/handle/123456789/569893Sealing of exposed dentinal tubules is generally considered the most effective strategy to treat dentin hypersensitivity. On this account, we fabricated a DP-bioglass paste that created a homogeneous blockage on open dentinal tubules and formed a deep precipitate within dentinal tubules. DP-bioglass paste was prepared by mixing 20% to 60% phosphoric acid and DP-bioglass to treat dentin surfaces. CO2 laser irradiation was used to melt the DP-bioglass paste. The results demonstrated that 30% phosphoric acid was the optimum concentration to produce homogeneous occlusion on exposed dentinal tubules and 60 microm of sealing depth. CO2 laser irradiation could melt the DP-bioglass paste and create about 10 microm of sealing depth. Moreover, temperature rise during CO2 laser irradiation was only 4.86 +/- 0.47 degrees C. The results presented in this work suggested that DP-bioglass paste could produce considerable sealing depth in dentinal tubules with the potential of prolonging the therapeutic effect efficaciously.[SDGs]SDG6journal article10.4012/dmj.24.5622-s2.0-33644824204