YI-CHENG CHANGChiu Y.-F.Lee I.-T.Ho L.-T.Hung Y.-J.Hsiung C.A.Quertermous T.Donlon T.Lee W.-J.PO-CHU LEEChen C.-H.Mochly-Rosen D.LEE-MING CHUANG2020-06-012020-06-0120121471-2261https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864223345&doi=10.1186%2f1471-2261-12-58&partnerID=40&md5=33609ae85a89579e6606c9144de5b42chttps://scholars.lib.ntu.edu.tw/handle/123456789/495528Background: Genetic variants near/within the ALDH2 gene encoding the mitochondrial aldehyde dehydrogenase 2 have been associated with blood pressure and hypertension in several case-control association studies in East Asian populations.Methods: Three common tag single nucleotide polymorphisms (tagSNP) in the ALDH2 gene were genotyped in 1,134 subjects of Chinese origin from the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance (SAPPHIRe) family cohort. We examined whether the ALDH2 SNP genotypes predicted the development of hypertension in the prospective SAPPHIRe cohort.Results: Over an average follow-up period of 5.7 years, carriers homozygous for the rs2238152 T allele in the ALDH2 gene were more likely to progress to hypertension than were non-carriers (hazard ratio [HR], 2.88, 95% confidence interval [CI], 1.06-7.84, P = 0.03), corresponding to a population attributable risk of ~7.1%. The risk associated with the rs2238152 T allele were strongest in heavy/moderate alcohol drinkers and was reduced in non-drinkers, indicating an interaction between ALDH2 genetic variants and alcohol intake on the risk of hypertension (P for interaction = 0.04). The risk allele was associated with significantly lower ALDH2 gene expression levels in human adipose tissue.Conclusion: ALDH2 genetic variants were associated with progression to hypertension in a prospective Chinese cohort. The association was modified by alcohol consumption. ? 2012 Chang et al.; licensee BioMed Central Ltd.[SDGs]SDG3messenger RNA; adipose tissue; adult; alcohol consumption; ALDH2 gene; allele; article; Chinese; cohort analysis; diastolic blood pressure; disease course; female; follow up; gene; gene expression; gene frequency; genotype; genotype environment interaction; homozygosity; human; human tissue; hypertension; major clinical study; male; morbid obesity; pathogenesis; priority journal; risk assessment; single nucleotide polymorphism; systolic blood pressure; Adipose Tissue; Adult; Alcohol Drinking; Aldehyde Dehydrogenase; Asian Continental Ancestry Group; Blood Pressure; China; Disease Progression; Female; Gene Frequency; Gene-Environment Interaction; Genetic Predisposition to Disease; Homozygote; Humans; Hypertension; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Prospective Studies; Risk Assessment; Risk Factors; Taiwan; Time Factors; Young Adultjournal article10.1186/1471-2261-12-58228392152-s2.0-84864223345