Lo Y.-C.Chen M.-Y.WANG-HUEI SHENGSZU-MIN HSIEHHSIN-YUN SUNLiu W.-C.Wu P.-Y.Wu C.-H.CHIEN-CHING HUNGSHAN-CHWEN CHANG2020-12-292020-12-2920091464-2662https://www.scopus.com/inward/record.uri?eid=2-s2.0-65449131159&doi=10.1111%2fj.1468-1293.2008.00687.x&partnerID=40&md5=6afae5cf08594fdc7ef100faa2730293https://scholars.lib.ntu.edu.tw/handle/123456789/535292Objectives: Recent studies suggest that patients with HIV infection are at increased risk for incident diabetes mellitus (DM). We investigated the incidence and risk factors of DM among HIV-infected patients receiving combination antiretroviral therapy (CART) in Taiwan. Methods: Incident cases of DM were identified among HIV-infected patients at the National Taiwan University Hospital between 1993 and 2006. A retrospective case-control study was conducted after matching cases with controls for sex, age at HIV diagnosis, year of HIV diagnosis, mode of HIV transmission and baseline CD4 lymphocyte count. A multivariate analysis was performed to identify risk factors for incident DM among HIV-infected patients. Results: In 824 HIV-infected patients eligible for analysis, 50 cases of incident DM were diagnosed, resulting in an incidence of 13.1 cases per 1000 person-years of follow-up. In total, 100 matched controls were identified. Risk factors for incident DM were a family history of DM [odds ratio (OR) 2.656; 95% confidence interval (CI) 1.209-5.834], exposure to zidovudine (OR 3.168; 95% CI 1.159-8.661) and current use of protease inhibitors (OR 2.528; 95% CI 1.186-5.389). Conclusions: Incident DM was associated with a family history of DM, exposure to zidovudine and current use of protease inhibitors in HIV-infected patients receiving CART in Taiwan. ? 2009 British HIV Association.[SDGs]SDG3abacavir; antiretrovirus agent; atazanavir; didanosine; efavirenz; indinavir; lamivudine; lopinavir; nelfinavir; nevirapine; proteinase inhibitor; ritonavir; RNA directed DNA polymerase inhibitor; saquinavir; stavudine; zalcitabine; zidovudine; adolescent; adult; article; case control study; CD4 lymphocyte count; combination chemotherapy; controlled study; diabetes mellitus; drug exposure; family history; female; follow up; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; major clinical study; male; morbidity; priority journal; retrospective study; risk factor; Taiwan; virus transmission; Adolescent; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; China; Diabetes Mellitus; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epidemiologic Methods; Family Health; Female; HIV Infections; Humans; Male; Middle Aged; Taiwan; Young Adult; Zidovudinejournal article10.1111/j.1468-1293.2008.00687.x19220492