MING-WHEI YUWEI-LIANG SHIHLin C.-L.CHUN-JEN LIUJian J.-W.KEH-SUNG TSAIChen C.-J.2021-03-102021-03-1020080732-183Xhttps://scholars.lib.ntu.edu.tw/handle/123456789/551483Purpose: To determine prospectively whether body-mass index (BMI) is associated with liver-related morbidity and mortality among male hepatitis B virus (HBV) carriers. Patients and Methods: We performed a prospective study of 2,903 male HBV surface antigen-positive government employees who were free of cancer at enrollment between 1989 and 1992. Main outcome measures included ultrasonography, biochemical tests, incident hepatocellular carcinoma (HCC), and liver-related death. Results: During mean follow-up of 14.7 years, 134 developed HCC and 92 died as a result of liver-related causes. In Cox proportional hazards models adjusting for age, number of visits, diabetes, and use of alcohol and tobacco, the hazard ratios for incident HCC were 1.48 (95% CI, 1.04 to 2.12) in overweight men (BMI between 25.0 and 29.9 kg/m2) and 1.96 (95% CI, 0.72 to 5.38) in obese men (BMI ? 30.0 kg/m2), compared with normal-weight men (BMI between 18.5 and 24.9 kg/m2). Liver-related mortality had adjusted hazard ratios of 1.74 (95% CI, 1.15 to 2.65) in overweight men and 1.50 (95% CI, 0.36 to 6.19) in obese men. Excess BMI was also associated with the occurrence of fatty liver and cirrhosis detected by ultrasonography, as well as elevated ALT and γ-glutamyltransferase (GGT) activity during follow-up. The association of BMI with GGT was stronger than with ALT, and elevated GGT activity and cirrhosis were the strongest predictors for incident HCC and liver-related death. Conclusion: This longitudinal cohort study indicates that excess body weight is involved in the transition from healthy HBV carrier state to HCC and liver-related death among men. ? 2008 by American Society of Clinical Oncology.[SDGs]SDG3aminotransferase; gamma glutamyltransferase; adult; alcohol consumption; article; body mass; controlled study; disease association; disease course; echography; enzyme activity; fatty liver; follow up; hepatitis B; human; liver cell carcinoma; liver cirrhosis; major clinical study; male; obesity; priority journal; smoking habit; Adult; Body Mass Index; Carcinoma, Hepatocellular; Cohort Studies; Hepatitis B; Hepatitis B virus; Humans; Liver Diseases; Liver Neoplasms; Male; Middle Aged; Overweight; Proportional Hazards Models; Prospective Studies; Treatment Outcomejournal article10.1200/JCO.2008.16.1075189554572-s2.0-57149086471